APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice
نویسندگان
چکیده
منابع مشابه
Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice.
Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Ang II and forms Ang-(1-7), has been suggested as a target against atherosclerosis. Here we investigated the actions of diminazene, a recently developed ACE2 activator compound, in a model of vulnerable ather...
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Microglia are a primary cellular component of the CNS innate immune system. Their response to conserved pathogen motifs is inherent and leads to the release of cytoactive factors that impact surrounding neurons and glia. The microglial response is modified by the local tissue environment and by "global" factors such as gender. Exposure to estrogen and testosterone, in general, down regulate mic...
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Experimental models of atherosclerosis suggest that recruitment of monocytes into plaques drives the progression of this chronic inflammatory condition. Cholesterol-lowering therapy leads to plaque stabilization or regression in human atherosclerosis, characterized by reduced macrophage content, but the mechanisms that underlie this reduction are incompletely understood. Mice lacking the gene A...
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In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele.
متن کاملAPOE genotype and Alzheimer’s immunotherapy
Alzheimer’s disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. AD risk is foremost modified by allelic composition of the APOE gene encoding apolipoprotein (apo) E-brain’s main lipid carrying protein. Emerging evidence suggests that APOE genotype also may modulate efficacy and safety of AD immunotherapy, which is under development as a potential disease-m...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2019
ISSN: 2051-5960
DOI: 10.1186/s40478-019-0729-z